RETROMINE, OR HOW TO PROVIDE IN-DEPTH RETROSPECTIVE STUDIES FROM MEDLINE IN A GLANCE: THE HEPCIDIN USE-CASE


A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon.

Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains.The antiviral cytokine, interferon (IFN) is an essential mediator of the innate immune response RAW HONEY and influenza viruses, like many viruses, have evolved strategies to evade

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TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells.

Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout.We introduced an inducible degron tag into the native TRPS1 locus within a luminal breast cancer cell line to identify the direct target

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